First ever state sepsis regulation in U.S. tied to lower death rates
Death rates from sepsis fell faster in New York than expected - and faster than in peer states - following the introduction of the nation’s first state-mandated sepsis regulation, reports Newswise, citing an analysis led by University of Pittsburgh researchers and published in JAMA. The policy requires all New York hospitals to quickly implement certain protocols when the deadly condition is suspected.
The finding is good news for the near dozen other states in varying stages of adopting similar policies to reduce deaths from sepsis, the leading cause of death in hospitalized patients.
“Rarely in the U.S. do we force hospitals to implement specific clinical protocols. Typically, quality improvement is achieved through financial incentives and public reporting,” said lead author Jeremy Kahn, MD, MS, professor in the Department of Critical Care Medicine at Pitt’s School of Medicine and the Department of Health Policy and Management at Pitt’s Graduate School of Public Health. “For the first time, state officials are enshrining in regulations that hospitals must follow certain evidence-based protocols when it comes to sepsis. And our study finds that, at least in New York, it seemed to work.”
Rory’s Regulations were issued by the New York State Department of Health in 2013 after 12-year-old Rory Staunton died of undiagnosed sepsis. The regulations require that hospitals in New York follow protocols for sepsis that include giving antibiotics within three hours and intravenous fluids within six hours of hospitalization. The hospitals also are required to regularly train staff in the protocols and to report adherence and clinical outcomes to the state.
Kahn and his team analyzed records of more than a million sepsis admissions in 509 hospitals in New York and four control states without a sepsis regulation: Florida, Maryland, Massachusetts and New Jersey. The team looked at dates from two years before Rory’s Regulations were adopted, and two years after.
In the years before the regulations went into place, 26.3 percent of the people diagnosed with sepsis in New York died while hospitalized, compared to a rate of 22 percent in the control states. Following the regulations, New York’s sepsis mortality rate dropped 4.3 percent to 22 percent, but the death rate only fell 2.9 percent to 19.1 percent in the control states.
After accounting for patient and hospital characteristics, as well as pre-existing sepsis trends in the states, New York’s sepsis death rate was 3.2 percent lower following the regulation than would have been expected, relative to the control states. This comparison was crucial to estimating the improvement and sets this study apart from prior work. Sepsis outcomes are known to improve over time - a study just looking in New York would not be able to differentiate the effects of the regulations from underlying trends. Because these improvements occurred more quickly in New York compared to other states, the researchers are more confident that the regulations are the source of the improvement.
